Sean Crawford

15 Feb 2024 · Coroner Crispin Oliver · County Durham and Darlington

The coroner's concerns

1. combined toxic effect of clozapine and alcohol
“The circumstances in which [the deceased] came by his death, the combined effects of clozapine with alcohol, seems to be, statistically, very rare”
2. central nervous system depression
“Death from Central Nervous System Depression, over-sedation, is not uncommon”
3. lack of warning about death risk
“the leaflet that comes with the Clozaril (clozapine) packages clearly states that it must not be taken with alcohol,”

Stated action · this year

“we intend to conduct a further assessment of the information provided within the clozapine product information regarding drug-drug interactions.”